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Target
Mannose-6-phosphate isomerase
Ligand
BDBM53630
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
11117±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM53630
Synonyms:
2-(5-{[3-(1,3-benzodioxol-5-yl)-2-imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl}-2-furyl)benzoic acid | 2-[5-[(Z)-[2-azanylidene-3-(1,3-benzodioxol-5-yl)-4-oxidanylidene-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]benzoic acid | 2-[5-[(Z)-[3-(1,3-benzodioxol-5-yl)-2-imino-4-keto-thiazolidin-5-ylidene]methyl]-2-furyl]benzoic acid | 2-[5-[(Z)-[3-(1,3-benzodioxol-5-yl)-2-imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]benzoic acid | 2-[5-[(Z)-[3-(1,3-benzodioxol-5-yl)-2-imino-4-oxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoic acid | MLS000673958 | SMR000298029 | cid_1360856
Type:
Small organic molecule
Emp. Form.:
C22H14N2O6S
Mol. Mass.:
434.421
SMILES:
OC(=O)c1ccccc1-c1ccc(\C=C2/SC(=N)N(C2=O)c2ccc3OCOc3c2)o1
Structure:
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