Reaction Details Report a problem with these data
Target
Cell division control protein 42 homolog
Ligand
BDBM54601
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
EC50
24378±n/a nM
Citation
 PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant PubChem Bioassay (2009)[AID] 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM54601
Synonyms:
UNM-0000305839 | [4-(2,3-diphenyl-3,4-dihydropyrazol-5-yl)phenyl] acetate | [4-(2,3-diphenyl-3,4-dihydropyrazol-5-yl)phenyl] ethanoate | acetic acid [4-(1,5-diphenyl-2-pyrazolin-3-yl)phenyl] ester | acetic acid [4-(2,3-diphenyl-3,4-dihydropyrazol-5-yl)phenyl] ester | cid_2849108
Type:
Small organic molecule
Emp. Form.:
C23H20N2O2
Mol. Mass.:
356.4171
SMILES:
CC(=O)Oc1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1ccccc1 |t:11|
Structure:
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