Reaction Details Report a problem with these data
Target
Cell division control protein 42 homolog
Ligand
BDBM54687
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
EC50
18621±n/a nM
Citation
 PubChem, PC Additional SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant PubChem Bioassay (2009)[AID] 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM54687
Synonyms:
2-amino-5-benzoyl-1-butylsulfonyl-4-(3,4,5-trimethoxyphenyl)-3-pyrrolecarbonitrile | 2-amino-5-benzoyl-1-butylsulfonyl-4-(3,4,5-trimethoxyphenyl)pyrrole-3-carbonitrile | 2-azanyl-1-butylsulfonyl-5-(phenylcarbonyl)-4-(3,4,5-trimethoxyphenyl)pyrrole-3-carbonitrile | UNM-0000305777 | cid_25220928
Type:
Small organic molecule
Emp. Form.:
C25H27N3O6S
Mol. Mass.:
497.563
SMILES:
CCCCS(=O)(=O)n1c(N)c(C#N)c(c1C(=O)c1ccccc1)-c1cc(OC)c(OC)c(OC)c1
Structure:
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