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Target
Ras-related protein Rab-7a
Ligand
BDBM54583
Substrate
n/a
Meas. Tech.
Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype
Ki
20±n/a nM
Citation
 PubChem, PC Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related protein Rab-7a
Synonyms:
GTP-binding protein (rab7) | RAB7 | RAB7A | RAB7A_CANLF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23519.50
Organism:
Canis lupus familiaris
Description:
gi_164058
Residue:
207
Sequence:
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKTSAESCSC
  
Inhibitor
Name:
BDBM54583
Synonyms:
1-[4-(2,5-dimethylphenyl)-1-piperazinyl]-3-[3-(4-methoxyphenyl)-5-isoxazolyl]-1-propanone | 1-[4-(2,5-dimethylphenyl)piperazin-1-yl]-3-[3-(4-methoxyphenyl)-1,2-oxazol-5-yl]propan-1-one | 1-[4-(2,5-dimethylphenyl)piperazino]-3-[3-(4-methoxyphenyl)isoxazol-5-yl]propan-1-one | KUC103430N | UNM-0000306149 | cid_44143705
Type:
Small organic molecule
Emp. Form.:
C25H29N3O3
Mol. Mass.:
419.5161
SMILES:
COc1ccc(cc1)-c1cc(CCC(=O)N2CCN(CC2)c2cc(C)ccc2C)on1
Structure:
Search PDB for entries with ligand similarity: