Reaction Details Report a problem with these data
Target
Ras-related protein Rab-7a
Ligand
BDBM54607
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related protein Rab-7a
Synonyms:
GTP-binding protein (rab7) | RAB7 | RAB7A | RAB7A_CANLF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23519.50
Organism:
Canis lupus familiaris
Description:
gi_164058
Residue:
207
Sequence:
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKTSAESCSC
  
Inhibitor
Name:
BDBM54607
Synonyms:
4-(2,5-diphenyl-3,4-dihydropyrazol-3-yl)-N,N-dimethyl-aniline | 4-(2,5-diphenyl-3,4-dihydropyrazol-3-yl)-N,N-dimethylaniline | UNM-0000305845 | [4-(2,5-diphenyl-2-pyrazolin-3-yl)phenyl]-dimethyl-amine | cid_2729182
Type:
Small organic molecule
Emp. Form.:
C23H23N3
Mol. Mass.:
341.4488
SMILES:
CN(C)c1ccc(cc1)C1CC(=NN1c1ccccc1)c1ccccc1 |c:12|
Structure:
Search PDB for entries with ligand similarity: