Reaction Details
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Ras-related protein Rab-2A
Ligand
BDBM54622
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
EC50
30000±n/a nM
Comments
Extracted from aid = 2045 and tid = 2
Citation
PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype PubChem Bioassay (2016)[AID] More Info.:
Target
Name:
Ras-related protein Rab-2A
Synonyms:
RAB2 | RAB2A | RAB2A_CANLF | Ras-related protein Rab-2A.
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23545.28
Organism:
Canis lupus familiaris
Description:
gi_46577642
Residue:
212
Sequence:
MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
Inhibitor
Name:
BDBM54622
Synonyms:
3-(3,4-dimethoxyphenyl)-2-(3-fluorophenyl)-5-(4-fluorophenyl)-3,4-dihydropyrazole | 5-(3,4-dimethoxyphenyl)-1-(3-fluorophenyl)-3-(4-fluorophenyl)-2-pyrazoline | UNM-0000305861 | cid_2883119
Type:
Small organic molecule
Emp. Form.:
C23H20F2N2O2
Mol. Mass.:
394.4139
SMILES:
COc1ccc(cc1OC)C1CC(=NN1c1cccc(F)c1)c1ccc(F)cc1 |c:13|
Structure:
