Reaction Details Report a problem with these data
Target
GTPase KRas [1-37]
Ligand
BDBM54622
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
GTPase KRas [1-37]
Synonyms:
ras protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4034.04
Organism:
Homo sapiens (Human)
Description:
gi_190938
Residue:
37
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
  
Inhibitor
Name:
BDBM54622
Synonyms:
3-(3,4-dimethoxyphenyl)-2-(3-fluorophenyl)-5-(4-fluorophenyl)-3,4-dihydropyrazole | 5-(3,4-dimethoxyphenyl)-1-(3-fluorophenyl)-3-(4-fluorophenyl)-2-pyrazoline | UNM-0000305861 | cid_2883119
Type:
Small organic molecule
Emp. Form.:
C23H20F2N2O2
Mol. Mass.:
394.4139
SMILES:
COc1ccc(cc1OC)C1CC(=NN1c1cccc(F)c1)c1ccc(F)cc1 |c:13|
Structure:
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