Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM55027
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3).
IC50
>36268±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3). PubChem Bioassay (2009)[AID] 
Target
Name:
Genome polyprotein
Synonyms:
NS3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67067.41
Organism:
Hepatitis C virus
Description:
gi_125541954
Residue:
631
Sequence:
APITAYAQQTRGLLGCIITGLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGSAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT
  
Inhibitor
Name:
BDBM55027
Synonyms:
2-(4-amoxy-3-methoxy-benzylidene)-6-phenyl-thiazolo[3,2-b][1,2,4]triazine-3,7-quinone | 2-[(3-methoxy-4-pentoxy-phenyl)methylidene]-6-phenyl-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione | 2-[(3-methoxy-4-pentoxyphenyl)methylidene]-6-phenyl-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione | 2-[(3-methoxy-4-pentoxyphenyl)methylidene]-6-phenylthiazolo[3,2-b][1,2,4]triazine-3,7-dione | 2-[1-(3-Methoxy-4-pentyloxy-phenyl)-meth-(Z)-ylidene]-6-phenyl-thiazolo[3,2-b][1,2,4]triazine-3,7-dione | MLS000588416 | SMR000212215 | cid_3839930
Type:
Small organic molecule
Emp. Form.:
C24H23N3O4S
Mol. Mass.:
449.522
SMILES:
CCCCCOc1ccc(C=c2sc3nc(=O)c(nn3c2=O)-c2ccccc2)cc1OC
Structure:
Search PDB for entries with ligand similarity: