Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM50394
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3).
IC50
25873±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3). PubChem Bioassay (2009)[AID] 
Target
Name:
Genome polyprotein
Synonyms:
NS3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67067.41
Organism:
Hepatitis C virus
Description:
gi_125541954
Residue:
631
Sequence:
APITAYAQQTRGLLGCIITGLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGSAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT
  
Inhibitor
Name:
BDBM50394
Synonyms:
(5E)-5-[(E)-3-(2-furanyl)prop-2-enylidene]-2-(4-methoxyanilino)-4-thiazolone | (5E)-5-[(E)-3-(2-furyl)prop-2-enylidene]-2-(p-anisidino)-2-thiazolin-4-one | (5E)-5-[(E)-3-(furan-2-yl)prop-2-enylidene]-2-(4-methoxyanilino)-1,3-thiazol-4-one | (5E)-5-[(E)-3-(furan-2-yl)prop-2-enylidene]-2-[(4-methoxyphenyl)amino]-1,3-thiazol-4-one | 5-[3-(2-furyl)-2-propenylidene]-2-[(4-methoxyphenyl)imino]-1,3-thiazolidin-4-one | MLS000699156 | SMR000228942 | cid_6206944
Type:
Small organic molecule
Emp. Form.:
C17H14N2O3S
Mol. Mass.:
326.37
SMILES:
COc1ccc(NC2=NC(=O)C(S2)=CC=Cc2ccco2)cc1 |w:13.14,15.16,t:7|
Structure:
Search PDB for entries with ligand similarity: