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Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50305818
Substrate
n/a
Meas. Tech.
Discovery of Novel Allosteric Modulators of the Muscarinic Receptor M5: Fold-shift Assay
EC50
>442±n/a nM
Comments
From 4.42E-7 on 20220115
Citation
 PubChem, PC Discovery of Novel Allosteric Modulators of the Muscarinic Receptor M5: Fold-shift Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_HUMAN | CHRM5
Type:
PROTEIN
Mol. Mass.:
60102.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517990
Residue:
532
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50305818
Synonyms:
1-(biphenyl-4-ylmethyl)-5-(trifluoromethoxy)indoline-2,3-dione | CHEMBL593506 | cid_45281794
Type:
Small organic molecule
Emp. Form.:
C22H14F3NO3
Mol. Mass.:
397.3467
SMILES:
FC(F)(F)Oc1ccc2N(Cc3ccc(cc3)-c3ccccc3)C(=O)C(=O)c2c1
Structure:
Search PDB for entries with ligand similarity: