Reaction Details Report a problem with these data
Target
Streptokinase A
Ligand
BDBM58079
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
11125±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM58079
Synonyms:
2-(2,4,6-Trifluoro-phenyl)-thiazolidine-3-carbothioic acid (3-trifluoromethyl-phenyl)-amide | MLS000332182 | N-[3-(trifluoromethyl)phenyl]-2-(2,4,6-trifluorophenyl)-1,3-thiazolidine-3-carbothioamide | N-[3-(trifluoromethyl)phenyl]-2-(2,4,6-trifluorophenyl)-3-thiazolidinecarbothioamide | N-[3-(trifluoromethyl)phenyl]-2-(2,4,6-trifluorophenyl)thiazolidine-3-carbothioamide | N-[3-(trifluoromethyl)phenyl]-2-[2,4,6-tris(fluoranyl)phenyl]-1,3-thiazolidine-3-carbothioamide | SMR000434844 | cid_4321852
Type:
Small organic molecule
Emp. Form.:
C17H12F6N2S2
Mol. Mass.:
422.411
SMILES:
Fc1cc(F)c(C2SCCN2C(=S)Nc2cccc(c2)C(F)(F)F)c(F)c1
Structure:
Search PDB for entries with ligand similarity: