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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM59254
Substrate
n/a
Meas. Tech.
uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay
EC50
100000±n/a nM
Citation
 PubChem, PC uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM59254
Synonyms:
7-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid (5-methyl-[1,3,4]thiadiazol-2-yl)-amide | 7-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-imidazo[1,2-a]pyridinecarboxamide | 7-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)imidazo[1,2-a]pyridine-2-carboxamide | MLS000071575 | SMR000003260 | cid_651198
Type:
Small organic molecule
Emp. Form.:
C12H11N5OS
Mol. Mass.:
273.314
SMILES:
Cc1nnc(NC(=O)c2cn3ccc(C)cc3n2)s1
Structure:
Search PDB for entries with ligand similarity: