Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM59255
Substrate
n/a
Meas. Tech.
uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay
EC50
100000±n/a nM
Citation
 PubChem, PC uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM59255
Synonyms:
1-(phenylmethyl)-3-[1-(4-phenylpiperazin-1-yl)carbonylcyclohexyl]urea | 1-Benzyl-3-[1-(4-phenyl-piperazine-1-carbonyl)-cyclohexyl]-urea | 1-[1-[oxo-(4-phenyl-1-piperazinyl)methyl]cyclohexyl]-3-(phenylmethyl)urea | 1-benzyl-3-[1-(4-phenylpiperazine-1-carbonyl)cyclohexyl]urea | MLS000027834 | SMR000000431 | cid_653801
Type:
Small organic molecule
Emp. Form.:
C25H32N4O2
Mol. Mass.:
420.5472
SMILES:
O=C(NCc1ccccc1)NC1(CCCCC1)C(=O)N1CCN(CC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: