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Target
Tumor necrosis factor
Ligand
BDBM59547
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction revised
IC50
>20000±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction revised PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM59547
Synonyms:
(4Z)-4-(3-bromo-4-hydroxy-5-methoxy-benzylidene)-1-(3-chlorophenyl)pyrazolidine-3,5-quinone | (4Z)-4-[(3-bromanyl-5-methoxy-4-oxidanyl-phenyl)methylidene]-1-(3-chlorophenyl)pyrazolidine-3,5-dione | (4Z)-4-[(3-bromo-4-hydroxy-5-methoxyphenyl)methylidene]-1-(3-chlorophenyl)pyrazolidine-3,5-dione | 4-(3-Bromo-4-hydroxy-5-methoxy-benzylidene)-1-(3-chloro-phenyl)-pyrazolidine-3,5-dione | MLS001210835 | SMR000514643 | cid_1108981
Type:
Small organic molecule
Emp. Form.:
C17H12BrClN2O4
Mol. Mass.:
423.645
SMILES:
COc1cc(\C=C2\C(=O)NN(C2=O)c2cccc(Cl)c2)cc(Br)c1O
Structure:
Search PDB for entries with ligand similarity: