Target
Serine/threonine-protein kinase Sgk1
Ligand
BDBM268659
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
pH
7.4±n/a
IC50
<1.20±n/a nM
Comments
extracted
Citation
 Nazare, MHalland, NSchmidt, FKleemann, HWeiss, TSaas, JStruebing, C N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals US Patent  US9718825 Publication Date 8/1/2017 
Target
Name:
Serine/threonine-protein kinase Sgk1
Synonyms:
SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1)
Type:
Other Protein Type
Mol. Mass.:
48954.40
Organism:
Homo sapiens (Human)
Description:
Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:
431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
  
Inhibitor
Name:
BDBM268659
Synonyms:
US9718825, Example 61
Type:
Small organic molecule
Emp. Form.:
C23H21Cl2N5O4S
Mol. Mass.:
534.415
SMILES:
OC1CCC(CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1 |(2.51,7.8,;3.28,6.46,;4.82,6.46,;5.59,5.13,;4.82,3.79,;3.28,3.79,;2.51,5.13,;5.59,2.46,;4.82,1.13,;3.28,1.13,;2.51,-.21,;3.28,-1.54,;4.82,-1.54,;5.85,-2.68,;7.25,-2.06,;7.09,-.53,;5.59,-.21,;.97,-.21,;.2,-1.54,;-1.34,-1.54,;-2.11,-.21,;-3.65,-.21,;-4.42,-1.54,;-5.19,-2.87,;-3.09,-2.31,;-5.76,-.77,;-5.76,.77,;-7.09,1.54,;-7.09,3.08,;-8.43,.77,;-8.43,-.77,;-7.09,-1.54,;-7.09,-3.08,;-1.34,1.13,;.2,1.13,)|
Structure:
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