Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63388
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63388
Synonyms:
3-acetyl-4-hydroxy-2-(4-hydroxyphenyl)-1-(3-pyridinylmethyl)-2H-pyrrol-5-one | 3-acetyl-4-hydroxy-2-(4-hydroxyphenyl)-1-(pyridin-3-ylmethyl)-2H-pyrrol-5-one | 3-ethanoyl-2-(4-hydroxyphenyl)-4-oxidanyl-1-(pyridin-3-ylmethyl)-2H-pyrrol-5-one | 4-acetyl-3-hydroxy-5-(4-hydroxyphenyl)-1-(3-pyridylmethyl)-3-pyrrolin-2-one | MLS000703434 | SMR000273898 | cid_3141399
Type:
Small organic molecule
Emp. Form.:
C18H16N2O4
Mol. Mass.:
324.3306
SMILES:
CC(=O)C1C(N(Cc2cccnc2)C(=O)C1=O)c1ccc(O)cc1
Structure:
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