Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63389
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63389
Synonyms:
1-({5-[(2-chloro-4-fluorophenoxy)methyl]isoxazol-3-yl}carbonyl)-2-(1-methyl-1H-imidazol-2-yl)piperidine | MLS000734588 | SMR000317835 | [5-[(2-chloranyl-4-fluoranyl-phenoxy)methyl]-1,2-oxazol-3-yl]-[2-(1-methylimidazol-2-yl)piperidin-1-yl]methanone | [5-[(2-chloro-4-fluoro-phenoxy)methyl]isoxazol-3-yl]-[2-(1-methylimidazol-2-yl)piperidino]methanone | [5-[(2-chloro-4-fluorophenoxy)methyl]-1,2-oxazol-3-yl]-[2-(1-methylimidazol-2-yl)piperidin-1-yl]methanone | [5-[(2-chloro-4-fluorophenoxy)methyl]-3-isoxazolyl]-[2-(1-methyl-2-imidazolyl)-1-piperidinyl]methanone | cid_16187346
Type:
Small organic molecule
Emp. Form.:
C20H20ClFN4O3
Mol. Mass.:
418.849
SMILES:
Cn1ccnc1C1CCCCN1C(=O)c1cc(COc2ccc(F)cc2Cl)on1
Structure:
Search PDB for entries with ligand similarity: