Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM54177
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 2
IC50
>20000±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54177
Synonyms:
MLS000107619 | N-[1-(4-chlorobenzyl)benzimidazol-2-yl]-2-furamide | N-[1-[(4-chlorophenyl)methyl]-2-benzimidazolyl]-2-furancarboxamide | N-[1-[(4-chlorophenyl)methyl]benzimidazol-2-yl]furan-2-carboxamide | SMR000103585 | cid_1034468
Type:
Small organic molecule
Emp. Form.:
C19H14ClN3O2
Mol. Mass.:
351.786
SMILES:
Clc1ccc(Cn2c(NC(=O)c3ccco3)nc3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: