Target
Gag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N]
Ligand
BDBM2278
Substrate
poly(rC)-oligo(dG)(12-18)
Meas. Tech.
HIV-1 RT Assay
pH
7.8±n/a
Temperature
310.15±n/a K
IC50
>5000±n/a nM
Citation
 Silvestri, RDe Martino, GLa Regina, GArtico, MMassa, SVargiu, LMura, MLoi, AGMarceddu, TLa Colla, P Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies. J Med Chem 46:2482-93 (2003) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N]
Synonyms:
EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (K103N)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [588-1147,K690N]
Synonyms:
HIV-1 Reverse Transcriptase Mutant (K103N) Chain A | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
64471.33
Organism:
Human immunodeficiency virus type 1
Description:
P04585[588-1147,K690N]
Residue:
560
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVL
  
Component 2
Name:
Gag-Pol polyprotein [588-1027,K690N]
Synonyms:
HIV-1 Reverse Transcriptase Mutant (K103N) Chain B | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
51280.01
Organism:
Human immunodeficiency virus type 1
Description:
P04585[588-1027,K690N]
Residue:
440
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYNLEKEPIVGAETF
  
Inhibitor
Name:
BDBM2278
Synonyms:
3-(benzenesulfonyl)-5-chloro-1H-indole-2-carboxamide | 5-Chloro-3-(phenylsulfonyl)-2-indolecarboxamide | 5Cl3PhSO2-2IndolCONH2 | L-737,126
Type:
Small organic molecule
Emp. Form.:
C15H11ClN2O3S
Mol. Mass.:
334.777
SMILES:
NC(=O)c1[nH]c2ccc(Cl)cc2c1S(=O)(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
poly(rC)-oligo(dG)(12-18)
Synonyms:
n/a
Type:
RNA/DNA duplex
Mol. Mass.:
358.43
Organism:
n/a
Description:
The incorporation of Tritium-labeled dGTP onto a poly(rC)-oligo(dG)(12-18) template-primer
Residue:
3
Sequence:
NA