Target
Guanine nucleotide-binding protein G(o) subunit alpha
Ligand
BDBM67700
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao with additional round of SAR compounds
EC50
>30000±0 nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao with additional round of SAR compounds PubChem Bioassay (2010)[AID] 
Target
Name:
Guanine nucleotide-binding protein G(o) subunit alpha
Synonyms:
GNAO1 | GNAO_HUMAN | Guanine nucleotide-binding protein G(o), alpha subunit 1 | guanine nucleotide-binding protein G(o) subunit alpha isoform a
Type:
PROTEIN
Mol. Mass.:
40043.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_321106
Residue:
354
Sequence:
MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
  
Inhibitor
Name:
BDBM67700
Synonyms:
3-chloranyl-6-nitro-1-benzothiophene-2-carboxamide | 3-chloro-6-nitro-1-benzothiophene-2-carboxamide | 3-chloro-6-nitro-benzothiophene-2-carboxamide | KSC-1-100 | KUC103873N | cid_874677
Type:
Small organic molecule
Emp. Form.:
C9H5ClN2O3S
Mol. Mass.:
256.666
SMILES:
NC(=O)c1sc2cc(ccc2c1Cl)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: