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Target
Tyrosine-protein kinase ABL1 [1-999,Q252H]
Ligand
BDBM68213
Substrate
n/a
Meas. Tech.
Biochemcial Assay
pH
7.5±0
IC50
>5000±0.0 nM
Citation
 Okram, B; Nagle, A; Adrián, FJ; Lee, C; Ren, P; Wang, X; Sim, T; Xie, Y; Wang, X; Xia, G; Spraggon, G; Warmuth, M; Liu, Y; Gray, NS A general strategy for creating "inactive-conformation" abl inhibitors. Chem Biol 13:779-86 (2006) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase ABL1 [1-999,Q252H]
Synonyms:
ABL | ABL1 | ABL1(Q252H) | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL (Phosphorylated) | Tyrosine-protein kinase ABL (dephosphorylated)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
108590.01
Organism:
Homo sapiens (Human)
Description:
gi_62362414
Residue:
999
Sequence:
MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGHYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSS
  
Inhibitor
Name:
BDBM68213
Synonyms:
Type I progenitor, 7
Type:
Small organic molecule
Emp. Form.:
C20H18N4O2S
Mol. Mass.:
378.448
SMILES:
O=C(Nc1ccc(cc1)N1CCOCC1)c1cc2cnc3[nH]ccc3c2s1
Structure:
Search PDB for entries with ligand similarity: