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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM76206
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay
IC50
1630±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM76206
Synonyms:
1-(3,4-dihydroxyphenyl)-2-[4-(2-fluorophenyl)-1-piperazinyl]ethanone | 1-(3,4-dihydroxyphenyl)-2-[4-(2-fluorophenyl)piperazin-1-yl]ethanone | 1-(3,4-dihydroxyphenyl)-2-[4-(2-fluorophenyl)piperazino]ethanone | 1-[3,4-bis(oxidanyl)phenyl]-2-[4-(2-fluorophenyl)piperazin-1-yl]ethanone | MLS001202427 | SMR000564913 | cid_4122157
Type:
Small organic molecule
Emp. Form.:
C18H19FN2O3
Mol. Mass.:
330.3535
SMILES:
Oc1ccc(cc1O)C(=O)CN1CCN(CC1)c1ccccc1F
Structure:
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