Reaction Details Report a problem with these data
Target
Alkaline phosphatase, germ cell type
Ligand
BDBM65711
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase
EC50
73700±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, germ cell type
Synonyms:
ALPG | ALPPL | ALPPL2 | Alkaline phosphatase placental-like | PPBN_HUMAN | placental-like alkaline phosphatase preproprotein
Type:
PROTEIN
Mol. Mass.:
57374.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_29964
Residue:
532
Sequence:
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP
  
Inhibitor
Name:
BDBM65711
Synonyms:
1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-[4-(diethylamino)-6-oxo-1-cyclohexa-2,4-dienylidene]methyl]-5-propan-2-yl-4-triazolecarbohydrazide | 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-[4-(diethylamino)-6-oxocyclohexa-2,4-dien-1-ylidene]methyl]-5-propan-2-yltriazole-4-carbohydrazide | 1-(4-aminofurazan-3-yl)-N'-[(E)-[4-(diethylamino)-6-keto-cyclohexa-2,4-dien-1-ylidene]methyl]-5-isopropyl-triazole-4-carbohydrazide | 1-(4-azanyl-1,2,5-oxadiazol-3-yl)-N'-[(E)-[4-(diethylamino)-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene]methyl]-5-propan-2-yl-1,2,3-triazole-4-carbohydrazide | MLS001139440 | SMR000647146 | cid_5801628
Type:
Small organic molecule
Emp. Form.:
C19H25N9O3
Mol. Mass.:
427.4603
SMILES:
CCN(CC)c1ccc(C=NNC(=O)c2nnn(-c3nonc3N)c2C(C)C)c(O)c1 |w:10.10|
Structure:
Search PDB for entries with ligand similarity: