Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM58233
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
5240±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM58233
Synonyms:
2-amino-2-sulfanylidene-N-[4-(trifluoromethoxy)anilino]ethanimidoyl cyanide | 2-cyano-2-[[4-(trifluoromethoxy)phenyl]hydrazinylidene]ethanethioamide | 2-cyano-2-[[4-(trifluoromethoxy)phenyl]hydrazono]thioacetamide | 2-cyano-2-[[4-(trifluoromethyloxy)phenyl]hydrazinylidene]ethanethioamide | 2-cyano-2-{2-[4-(trifluoromethoxy)phenyl]hydrazono}ethanethioamide | MLS000834858 | SMR000461374 | cid_2744440
Type:
Small organic molecule
Emp. Form.:
C10H7F3N4OS
Mol. Mass.:
288.249
SMILES:
NC(=S)C(=NNc1ccc(OC(F)(F)F)cc1)C#N |w:4.4|
Structure:
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