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Target
Ubiquitin-conjugating enzyme E2 N
Ligand
BDBM78673
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm
IC50
709±21 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm PubChem Bioassay (2011)[AID] 
Target
Name:
Ubiquitin-conjugating enzyme E2 N
Synonyms:
BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N
Type:
PROTEIN
Mol. Mass.:
17137.61
Organism:
Homo sapiens (Human)
Description:
EBI_101440
Residue:
152
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
  
Inhibitor
Name:
BDBM78673
Synonyms:
6-[1,3-bis(oxidanylidene)isoindol-2-yl]-N-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)hexanamide | MLS000698275 | N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexanamide | N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-6-(1,3-dioxo-2-isoindolyl)hexanamide | N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-6-(1,3-dioxoisoindol-2-yl)hexanamide | N-(3-keto-1,5-dimethyl-2-phenyl-3-pyrazolin-4-yl)-6-phthalimido-hexanamide | SMR000225552 | cid_3524504
Type:
Small organic molecule
Emp. Form.:
C25H26N4O4
Mol. Mass.:
446.4983
SMILES:
Cc1c(NC(=O)CCCCCN2C(=O)c3ccccc3C2=O)c(=O)n(-c2ccccc2)n1C
Structure:
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