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Target
Ubiquitin-conjugating enzyme E2 N
Ligand
BDBM78782
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm
IC50
1314±43 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm PubChem Bioassay (2011)[AID] 
Target
Name:
Ubiquitin-conjugating enzyme E2 N
Synonyms:
BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N
Type:
PROTEIN
Mol. Mass.:
17137.61
Organism:
Homo sapiens (Human)
Description:
EBI_101440
Residue:
152
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
  
Inhibitor
Name:
BDBM78782
Synonyms:
4-[1-[(3-fluorophenyl)methyl]-2,4-bis(oxidanylidene)quinazolin-3-yl]-N-[1-(phenylmethyl)piperidin-4-yl]butanamide | 4-[1-[(3-fluorophenyl)methyl]-2,4-dioxo-3-quinazolinyl]-N-[1-(phenylmethyl)-4-piperidinyl]butanamide | MLS000730457 | N-(1-benzyl-4-piperidyl)-4-[1-(3-fluorobenzyl)-2,4-diketo-quinazolin-3-yl]butyramide | N-(1-benzylpiperidin-4-yl)-4-[1-(3-fluorobenzyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]butanamide | N-(1-benzylpiperidin-4-yl)-4-[1-[(3-fluorophenyl)methyl]-2,4-dioxoquinazolin-3-yl]butanamide | SMR000308733 | cid_16193615
Type:
Small organic molecule
Emp. Form.:
C31H33FN4O3
Mol. Mass.:
528.6171
SMILES:
Fc1cccc(Cn2c3ccccc3c(=O)n(CCCC(=O)NC3CCN(Cc4ccccc4)CC3)c2=O)c1
Structure:
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