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Target
Ubiquitin-conjugating enzyme E2 N
Ligand
BDBM65651
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm
IC50
1351±80 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm PubChem Bioassay (2011)[AID] 
Target
Name:
Ubiquitin-conjugating enzyme E2 N
Synonyms:
BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N
Type:
PROTEIN
Mol. Mass.:
17137.61
Organism:
Homo sapiens (Human)
Description:
EBI_101440
Residue:
152
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
  
Inhibitor
Name:
BDBM65651
Synonyms:
4-[(Z)-[4-(4-chlorobenzyl)-3-keto-1,4-benzoxazin-2-ylidene]methyl]-N-[3-(4-methylpiperazino)propyl]benzamide | 4-[(Z)-[4-[(4-chlorophenyl)methyl]-3-oxidanylidene-1,4-benzoxazin-2-ylidene]methyl]-N-[3-(4-methylpiperazin-1-yl)propyl]benzamide | 4-[(Z)-[4-[(4-chlorophenyl)methyl]-3-oxo-1,4-benzoxazin-2-ylidene]methyl]-N-[3-(4-methyl-1-piperazinyl)propyl]benzamide | 4-[(Z)-[4-[(4-chlorophenyl)methyl]-3-oxo-1,4-benzoxazin-2-ylidene]methyl]-N-[3-(4-methylpiperazin-1-yl)propyl]benzamide | MLS001030809 | SMR000635124 | cid_24792840
Type:
Small organic molecule
Emp. Form.:
C31H33ClN4O3
Mol. Mass.:
545.072
SMILES:
CN1CCN(CCCNC(=O)c2ccc(\C=C3/Oc4ccccc4N(Cc4ccc(Cl)cc4)C3=O)cc2)CC1
Structure:
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