Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 4
Ligand
BDBM79620
Substrate
n/a
Meas. Tech.
SAR Analysis for the identification of selective inhibits of the transient receptor potential cation channel C4 (TRPC4): Automated Electrophysiology_2
IC50
8900±n/a nM
Citation
 PubChem, PC SAR Analysis for the identification of selective inhibits of the transient receptor potential cation channel C4 (TRPC4): Automated Electrophysiology_2 PubChem Bioassay (2011)[AID] 
Target
Name:
Short transient receptor potential channel 4
Synonyms:
TRPC4_MOUSE | Trpc4 | Trrp4 | alternatively spliced Trp4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
111587.67
Organism:
Mus musculus
Description:
Q9QUQ5
Residue:
974
Sequence:
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISSFRFEVLGLLRGSKLSTIQSANAASSADSDEKSQSEGNGKDKRKNLSLFDLTTLIHPRSAAIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEEITRQQAAGALERNIELESKGLASRGDRSIPGLNEQCVLVDHRERNTDTLGLQVGKRVCSTFKSEKVVVEDTVPIIPKEKHAHEEDSSIDYDLSPTDTAAHEDYVTTRL
  
Inhibitor
Name:
BDBM79620
Synonyms:
2-[4-(4-methyl-2-quinolinyl)-1-piperazinyl]benzonitrile;2,2,2-trifluoroacetic acid | 2-[4-(4-methyl-2-quinolyl)piperazino]benzonitrile;2,2,2-trifluoroacetic acid | 2-[4-(4-methylquinolin-2-yl)piperazin-1-yl]benzenecarbonitrile;2,2,2-tris(fluoranyl)ethanoic acid | 2-[4-(4-methylquinolin-2-yl)piperazin-1-yl]benzonitrile;2,2,2-trifluoroacetic acid | VU0418911-1 | cid_46259346
Type:
Small organic molecule
Emp. Form.:
C21H20N4
Mol. Mass.:
328.4103
SMILES:
Cc1cc(nc2ccccc12)N1CCN(CC1)c1ccccc1C#N
Structure:
Search PDB for entries with ligand similarity: