Target
Bis(5'-adenosyl)-triphosphatase
Ligand
BDBM81576
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
Ki
35±0.0 nM
Citation
 Varnum, JMBaraniak, JKaczmarek, RStec, WJBrenner, C Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement. BMC Chem Biol 1:3 (2001) [PubMed]  Article 
Target
Name:
Bis(5'-adenosyl)-triphosphatase
Synonyms:
AP3A hydrolase | AP3Aase | Bis(5'adenosyl)-triphosphatase | Dinucleosidetriphosphatase | FHIT | FHIT_HUMAN | Fragile histidine triad protein
Type:
Protein
Mol. Mass.:
16861.00
Organism:
Homo sapiens (Human)
Description:
P49789
Residue:
147
Sequence:
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKHDKEDFPASWRSEEEMAAEAAALRVYFQ
  
Inhibitor
Name:
BDBM81576
Synonyms:
AppppA analog, 6 (X=S)
Type:
Small organic molecule
Emp. Form.:
C23H30N10O13P2S2
Mol. Mass.:
780.622
SMILES:
Nc1ncnc2n(cnc12)C1OC(COP([O-])(=S)OCC(O)COP([S-])(=O)OCC2OC(C(O)C2O)n2cnc3c(N)ncnc23)C(O)C1O
Structure:
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