Reaction Details Report a problem with these data
Target
Urokinase-type plasminogen activator
Ligand
BDBM81597
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
9e+3± 1e+3 nM
Citation
 Heynekamp, JJ; Hunsaker, LA; Vander Jagt, TA; Deck, LM; Vander Jagt, DL Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator. BMC Chem Biol 6:1 (2006) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM81597
Synonyms:
Isocoumarin, 4d
Type:
Small organic molecule
Emp. Form.:
C12H10BrClO3
Mol. Mass.:
317.563
SMILES:
Clc1c(OCCCBr)oc(=O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: