Reaction Details Report a problem with these data
Target
Urokinase-type plasminogen activator
Ligand
BDBM81603
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
20± 3 nM
Citation
 Heynekamp, JJ; Hunsaker, LA; Vander Jagt, TA; Deck, LM; Vander Jagt, DL Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator. BMC Chem Biol 6:1 (2006) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM81603
Synonyms:
Isocoumarin, 7a
Type:
Small organic molecule
Emp. Form.:
C12H12ClN3O3S
Mol. Mass.:
313.76
SMILES:
NC(=N)SCCOc1oc(=O)c2cc(N)ccc2c1Cl
Structure:
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