Reaction Details Report a problem with these data
Target
Carboxypeptidase B2
Ligand
BDBM81903
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
1.45e+5±n/a nM
Citation
 Fernández, D; Avilés, FX; Vendrell, J Aromatic organic compounds as scaffolds for metallocarboxypeptidase inhibitor design. Chem Biol Drug Des 73:75-82 (2009) [PubMed]  Article 
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM81903
Synonyms:
2-amino-3-(1-aminoisoquinolin-7-yl)propanoic acid, 2
Type:
Small organic molecule
Emp. Form.:
C12H13N3O2
Mol. Mass.:
231.2505
SMILES:
NC(Cc1ccc2ccnc(N)c2c1)C(O)=O
Structure:
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