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Target
Carboxypeptidase B2
Ligand
BDBM47512
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
5.0e+4±n/a nM
Citation
 Fernández, D; Avilés, FX; Vendrell, J Aromatic organic compounds as scaffolds for metallocarboxypeptidase inhibitor design. Chem Biol Drug Des 73:75-82 (2009) [PubMed]  Article 
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM47512
Synonyms:
1-(4-methylphenyl)-2-[[5-(8-quinolinyloxymethyl)-1,3,4-oxadiazol-2-yl]thio]ethanone | 1-(4-methylphenyl)-2-[[5-(quinolin-8-yloxymethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone | 1-(p-tolyl)-2-[[5-(8-quinolyloxymethyl)-1,3,4-oxadiazol-2-yl]thio]ethanone | 2-[5-(Quinolin-8-yloxymethyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-1-p-tolyl-ethanone | MLS000071760 | SMR000003497 | cid_650551
Type:
Small organic molecule
Emp. Form.:
C21H17N3O3S
Mol. Mass.:
391.443
SMILES:
Cc1ccc(cc1)C(=O)CSc1nnc(COc2cccc3cccnc23)o1
Structure:
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