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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM83449
Substrate
n/a
Ki
1000±n/a nM
Comments
PDSP_1440
Citation
 Korstanje, C; Sprenkels, R; Doods, HN; Hugtenburg, JG; Boddeke, E; Batink, HD; Thoolen, MJ; Van Zwieten, PA Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in-vivo alpha 1-,alpha 2- and 5-HT2-receptor antagonism and in-vitro affinity for alpha 1-,alpha 2- and 5-HT2-receptors: comparison with ketanserin. J Pharm Pharmacol 38:374-9 (1986) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM83449
Synonyms:
1-(1-phenylcyclohexyl)piperidine;hydrochloride | MLS002320664 | PCP | PCP hydrochloride | PHENCYCLIDINE | Phencyclidine hydrochloride | SMR001338811 | cid_9795678
Type:
Small organic molecule
Emp. Form.:
C17H25N
Mol. Mass.:
243.3871
SMILES:
C1CCN(CC1)C1(CCCCC1)c1ccccc1
Structure:
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