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Target
Carbonic anhydrase 6
Ligand
BDBM50137677
Substrate
n/a
Meas. Tech.
Enzyme Inhbition Assay
pH
7.5±0
Temperature
293.15±0 K
Ki
0.64±0 nM
Citation
 Winum, JY; Montero, JL; Vullo, D; Supuran, CT Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI. Chem Biol Drug Des 74:636-9 (2009) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 6
Synonyms:
CA-VI | CA6 | CAH6_HUMAN | Carbonate dehydratase VI | Carbonic Anhydrase VI | Carbonic anhydrase | Carbonic anhydrase 6 | Carbonic anhydrase 6 (CA VI) | Carbonic anhydrase 6 (CA-VI) | Carbonic anhydrase VI (CA VI) | Salivary carbonic anhydrase | Secreted carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
35371.40
Organism:
Homo sapiens (Human)
Description:
P23280
Residue:
308
Sequence:
MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN
  
Inhibitor
Name:
BDBM50137677
Synonyms:
4-(3,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylamino)-benzenesulfonamide | CHEMBL72447 | N-(p-sulfamoylphenyl)-alpha-glycopyranosylamine, 1 | N-(p-sulfamoylphenyl)-alpha-glycopyranosylamine, 2 | N-(p-sulfamoylphenyl)-alpha-glycopyranosylamine, 3
Type:
Small organic molecule
Emp. Form.:
C12H18N2O7S
Mol. Mass.:
334.346
SMILES:
NS(=O)(=O)c1ccc(NC2OC(CO)C(O)C(O)C2O)cc1
Structure:
Search PDB for entries with ligand similarity: