Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM82435
Substrate
n/a
Ki
570±n/a nM
Comments
PDSP_1025
Citation
 Beauchamp, HT; Chang, RS; Siegl, PK; Gibson, RE In vivo receptor occupancy of the angiotensin II receptor by nonpeptide antagonists: relationship to in vitro affinities and in vivo pharmacologic potency. J Pharmacol Exp Ther 272:612-8 (1995) [PubMed] 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM82435
Synonyms:
1-[2,4,6-Trichlorophenyl]-3-butyl-4-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-1H-pyrazole-5-carboxylic acid | L-161,276 | L-161276
Type:
Small organic molecule
Emp. Form.:
C28H23Cl3N6O2
Mol. Mass.:
581.88
SMILES:
CCCCc1nn(c(C(O)=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)-c1c(Cl)cc(Cl)cc1Cl |(13.29,.94,;11.96,.17,;10.62,.94,;9.29,.17,;7.95,.94,;7.79,2.47,;6.29,2.79,;5.52,1.46,;3.99,1.29,;3.36,-.11,;3.08,2.54,;6.55,.31,;6.23,-1.2,;7.37,-2.23,;7.05,-3.73,;8.2,-4.76,;9.66,-4.29,;9.98,-2.78,;8.84,-1.75,;10.8,-5.32,;12.27,-4.84,;13.41,-5.87,;13.09,-7.38,;11.63,-7.85,;10.48,-6.82,;9.02,-7.3,;7.77,-6.39,;6.53,-7.3,;7,-8.76,;8.54,-8.76,;5.91,4.28,;7.02,5.35,;8.5,4.93,;6.64,6.85,;5.16,7.27,;4.79,8.76,;4.06,6.2,;4.43,4.7,;3.32,3.63,)|
Structure:
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