Reaction Details
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Pituitary adenylate cyclase-activating polypeptide
Ligand
BDBM82449
Substrate
n/a
Ki
6000±n/a nM
Comments
PDSP_2425
Citation
Hou, X; Vandermeers, A; Gourlet, P; Vandermeers-Piret, MC; Robberecht, P Structural requirements for the occupancy of rat brain PACAP receptors and adenylate cyclase activation. Neuropharmacology 33:1189-95 (1994) [PubMed] Article More Info.:
Target
Name:
Pituitary adenylate cyclase-activating polypeptide
Synonyms:
Adcyap1 | PACAP | PACAP-27 | PACAP-38 | PACA_RAT | Pituitary adenylate cyclase-activating polypeptide
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19565.66
Organism:
RAT
Description:
PACAP 0 RAT::P13589
Residue:
175
Sequence:
MTMCSGARLALLVYGIIMHNSVSCSPAAGLSFPGIRPEEEAYDQDGNPLQDFYDWDPPGAGSPASALRDAYALYYPADRRDVAHEILNEAYRKVLDQLSARKYLQSMVARGMGENLAAAAVDDRAPLTKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL
Inhibitor
Name:
BDBM82449
Synonyms:
PACAP(11-27)
Type:
Small organic molecule
Emp. Form.:
C92H158N28O21S
Mol. Mass.:
2024.479
SMILES:
[#6]-[#16]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](-[#7])=O |r|
Structure:
