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Target
Beta-2 adrenergic receptor
Ligand
BDBM50019355
Substrate
n/a
Ki
22.9±n/a nM
Comments
PDSP_1890
Citation
 Fraundorfer, PF; Fertel, RH; Miller, DD; Feller, DR Biochemical and pharmacological characterization of high-affinity trimetoquinol analogs on guinea pig and human beta adrenergic receptor subtypes: evidence for partial agonism. J Pharmacol Exp Ther 270:665-74 (1994) [PubMed] 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2_CAVPO | Adrb2 | adrenergic Beta2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46993.24
Organism:
GUINEA PIG
Description:
adrenergic Beta2 ADRB2 GUINEA PIG::Q8K4Z4
Residue:
418
Sequence:
MGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL
  
Inhibitor
Name:
BDBM50019355
Synonyms:
1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-6,7-diol | 1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol | CHEMBL299175 | R(+)-TMQ | TMQ, Racemic | Tretoquinol
Type:
Small organic molecule
Emp. Form.:
C19H23NO5
Mol. Mass.:
345.3896
SMILES:
COc1cc(CC2NCCc3cc(O)c(O)cc23)cc(OC)c1OC
Structure:
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