Reaction Details Report a problem with these data
Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM80476
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
4513±148 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM80476
Synonyms:
MLS000856438 | SMR000279383 | [4-(1-methylpiperidin-1-ium-1-yl)-8-bicyclo[3.2.1]octanyl] acetate;iodide | [4-(1-methylpiperidin-1-ium-1-yl)-8-bicyclo[3.2.1]octanyl] ethanoate;iodide | acetic acid [4-(1-methyl-1-piperidin-1-iumyl)-8-bicyclo[3.2.1]octanyl] ester;iodide | acetic acid [4-(1-methylpiperidin-1-ium-1-yl)-8-bicyclo[3.2.1]octanyl] ester;iodide | cid_16192577
Type:
Small organic molecule
Emp. Form.:
C16H28NO2
Mol. Mass.:
266.3985
SMILES:
[H]C12CCC([H])(C1OC(C)=O)C(CC2)[N+]1(C)CCCCC1 |TLB:14:11:6:3.2|
Structure:
Search PDB for entries with ligand similarity: