Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM51249
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM51249
Synonyms:
6-(4-Nitro-phenyl)-2,3-diphenyl-imidazo[1,2-b][1,2,4]triazine | 6-(4-nitrophenyl)-2,3-diphenyl-imidazo[1,2-b][1,2,4]triazine | 6-(4-nitrophenyl)-2,3-diphenylimidazo[1,2-b][1,2,4]triazine | MLS000332678 | SMR000436068 | cid_342017
Type:
Small organic molecule
Emp. Form.:
C23H15N5O2
Mol. Mass.:
393.3975
SMILES:
[O-][N+](=O)c1ccc(cc1)-c1cn2nc(-c3ccccc3)c(nc2n1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: