Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM61896
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM61896
Synonyms:
2-(3,4-dihydroxyphenyl)-4-benzo[h][1]benzopyranone | 2-(3,4-dihydroxyphenyl)benzo[h]chromen-4-one | 2-[3,4-bis(oxidanyl)phenyl]benzo[h]chromen-4-one | 3',4'-DIHYDROXY-a-NAPHTHOFLAVONE | MLS001360569 | SMR001223866 | cid_676291
Type:
Small organic molecule
Emp. Form.:
C19H12O4
Mol. Mass.:
304.2962
SMILES:
Oc1ccc(cc1O)-c1cc(=O)c2ccc3ccccc3c2o1
Structure:
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