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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83785
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59629±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83785
Synonyms:
(5E)-1-benzyl-5-[(1-methylpyrrol-2-yl)methylene]barbituric acid | (5E)-1-benzyl-5-[(1-methylpyrrol-2-yl)methylidene]-1,3-diazinane-2,4,6-trione | (5E)-5-[(1-methyl-2-pyrrolyl)methylidene]-1-(phenylmethyl)-1,3-diazinane-2,4,6-trione | (5E)-5-[(1-methylpyrrol-2-yl)methylidene]-1-(phenylmethyl)-1,3-diazinane-2,4,6-trione | 1-Benzyl-5-[1-(1-methyl-1H-pyrrol-2-yl)-meth-(E)-ylidene]-pyrimidine-2,4,6-trione | MLS000587054 | SMR000211086 | cid_1916319
Type:
Small organic molecule
Emp. Form.:
C17H15N3O3
Mol. Mass.:
309.3193
SMILES:
Cn1cccc1\C=C1/C(=O)NC(=O)N(Cc2ccccc2)C1=O
Structure:
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