Reaction Details Report a problem with these data
Target
Apoptotic protease-activating factor 1
Ligand
BDBM34893
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay
IC50
1100±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay PubChem Bioassay (2011)[AID] 
Target
Name:
Apoptotic protease-activating factor 1
Synonyms:
APAF1 | APAF_HUMAN | Apoptotic peptidase activating factor 1 | KIAA0413
Type:
Enzyme Catalytic Domain
Mol. Mass.:
141834.40
Organism:
Homo sapiens (Human)
Description:
O14727
Residue:
1248
Sequence:
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
  
Inhibitor
Name:
BDBM34893
Synonyms:
6-N-(benzylideneamino)-2-N,2-N,4-N,4-N-tetramethylpyrimidine-2,4,6-triamine | MLS000709098 | N2,N2,N4,N4-tetramethyl-N6-[(phenylmethylene)amino]pyrimidine-2,4,6-triamine | N2,N2,N4,N4-tetramethyl-N6-[(phenylmethylidene)amino]pyrimidine-2,4,6-triamine | SMR000282965 | [4-(N'-benzalhydrazino)-6-(dimethylamino)pyrimidin-2-yl]-dimethyl-amine | [4-[(N''Z)-N''-benzalhydrazino]-6-(dimethylamino)pyrimidin-2-yl]-dimethyl-amine | [4-[(N'Z)-N'-benzalhydrazino]-6-(dimethylamino)pyrimidin-2-yl]-dimethyl-amine | cid_2853497
Type:
Small organic molecule
Emp. Form.:
C15H20N6
Mol. Mass.:
284.3595
SMILES:
CN(C)c1cc(N=NCc2ccccc2)nc(n1)N(C)C |w:6.5|
Structure:
Search PDB for entries with ligand similarity: