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TargetApoptotic peptidase activating factor 1
LigandBDBM71166
Substrate/Competitorn/a
Meas. Tech.Dose Response validation of Inhibitors of Apaf-1 using a Fluorescent Interference Counterscreen assay
IC50>100000±0 nM
Citation PubChem, PC Dose Response validation of Inhibitors of Apaf-1 using a Fluorescent Interference Counterscreen assay PubChem Bioassay(2011)[AID]
More Info.:Get all data from this article,  Assay Method
 
Apoptotic peptidase activating factor 1
Name:Apoptotic peptidase activating factor 1
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:141834.40
Organism:Homo sapiens (Human)
Description:O14727
Residue:1248
Sequence:
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH
STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM71166
NameBDBM71166
Synonyms:4-[Acetyl-(3-morpholin-4-yl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-amino]-benzoic acid | 4-[acetyl-(1,4-diketo-3-morpholino-2-naphthyl)amino]benzoic acid | 4-[acetyl-(3-morpholin-4-yl-1,4-dioxonaphthalen-2-yl)amino]benzoic acid | 4-[acetyl-[3-(4-morpholinyl)-1,4-dioxo-2-naphthalenyl]amino]benzoic acid | 4-[ethanoyl-[3-morpholin-4-yl-1,4-bis(oxidanylidene)naphthalen-2-yl]amino]benzoic acid | MLS000777527 | SMR000413921 | cid_2833927
TypeSmall organic molecule
Emp. Form.C23H20N2O6
Mol. Mass.420.4147
SMILESCC(=O)N(C1=C(N2CCOCC2)C(=O)c2ccccc2C1=O)c1ccc(cc1)C(O)=O |c:4|
Structure
n/a