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TargetCaspase-9
LigandBDBM71166
Substrate/Competitorn/a
Meas. Tech.Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
IC50 12700±n/a nM
Citation PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay(2011)[AID]
More Info.:Get all data from this article,  Assay Method
 
Caspase-9
Name:Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c
Synonyms:Apoptotic protease-activating factor 3 | CASP-9 | Caspase 9 | ICE-like apoptotic protease 6 | caspase-9 isoform alpha preproprotein
Type:Enzyme
Mol. Mass.:46277.29
Organism:Homo sapiens (Human)
Description:n/a
Residue:416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM71166
NameBDBM71166
Synonyms:4-[Acetyl-(3-morpholin-4-yl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-amino]-benzoic acid | 4-[acetyl-(1,4-diketo-3-morpholino-2-naphthyl)amino]benzoic acid | 4-[acetyl-(3-morpholin-4-yl-1,4-dioxonaphthalen-2-yl)amino]benzoic acid | 4-[acetyl-[3-(4-morpholinyl)-1,4-dioxo-2-naphthalenyl]amino]benzoic acid | 4-[ethanoyl-[3-morpholin-4-yl-1,4-bis(oxidanylidene)naphthalen-2-yl]amino]benzoic acid | MLS000777527 | SMR000413921 | cid_2833927
TypeSmall organic molecule
Emp. Form.C23H20N2O6
Mol. Mass.420.4147
SMILESCC(=O)N(C1=C(N2CCOCC2)C(=O)c2ccccc2C1=O)c1ccc(cc1)C(O)=O |c:4|
Structure
n/a