Reaction Details Report a problem with these data
Target
Alpha-mannosidase 2
Ligand
BDBM50088625
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
76±0 nM
Citation
 Kuntz, DA; Zhong, W; Guo, J; Rose, DR; Boons, GJ The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A. Chembiochem 10:268-77 (2009) [PubMed]  Article 
Target
Name:
Alpha-mannosidase 2
Synonyms:
Alpha-mannosidase 2 | GmII | Golgi alpha-mannosidase II | MAN2_DROME | alpha-Man-IIa
Type:
Protein
Mol. Mass.:
126735.79
Organism:
Drosophila melanogaster (Fruit fly)
Description:
Q24451
Residue:
1108
Sequence:
MLRIRRRFALVICSGCLLVFLSLYIILNFAAPAATQIKPNYENIENKLHELENGLQEHGEEMRNLRARLAETSNRDDPIRPPLKVARSPRPGQCQDVVQDVPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEMLSAWHSWDGMARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVGLPSVVHQTIMRGGAPEIRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSELHPAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSAREDLDVSVMRRLTKSSAKTQRVGYVLHRTNLMQCGTPEEHTQKLDVCHLLPNVARCERTTLTFLQNLEHLDGMVAPEVCPMETAAYVSSHSS
  
Inhibitor
Name:
BDBM50088625
Synonyms:
(1R,2R,3R,4S,5R)-4-Amino-5-methoxy-cyclopentane-1,2,3-triol | (1R,2R,3R,4S,5R)-4-amino-5-methoxycyclopentane-1,2,3-triol | CHEMBL427643 | Mannostatin analogue, 5
Type:
Small organic molecule
Emp. Form.:
C6H13NO4
Mol. Mass.:
163.1717
SMILES:
CO[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O
Structure:
Search PDB for entries with ligand similarity: