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Target
Substance-P receptor
Ligand
BDBM50000042
Substrate
n/a
Meas. Tech.
ChEBML_205879
Ki
49±n/a nM
Citation
 Desai, MC; Lefkowitz, SL; Thadeio, PF; Longo, KP; Snider, RM Discovery of a potent substance P antagonist: recognition of the key molecular determinant. J Med Chem 35:4911-3 (1993) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50000042
Synonyms:
(2-Benzhydryl-piperidin-3-yl)-(2-methoxy-benzyl)-amine | CHEMBL147543
Type:
Small organic molecule
Emp. Form.:
C26H30N2O
Mol. Mass.:
386.5292
SMILES:
COc1ccccc1CN[C@H]1CCCN[C@H]1C(c1ccccc1)c1ccccc1
Structure:
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