Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50000085
Substrate
n/a
Meas. Tech.
ChEBML_226551
Ki
1.5±n/a nM
Citation
 de Costa, BR; Radesca, L; Di Paolo, L; Bowen, WD Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor. J Med Chem 35:38-47 (1992) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50000085
Synonyms:
CHEMBL142297 | N*1*-[2-(3,4-Dichloro-phenyl)-ethyl]-N*1*,N*2*,N*2*-trimethyl-propane-1,2-diamine
Type:
Small organic molecule
Emp. Form.:
C14H22Cl2N2
Mol. Mass.:
289.244
SMILES:
CC(CN(C)CCc1ccc(Cl)c(Cl)c1)N(C)C
Structure:
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