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Target
Transmembrane prolyl 4-hydroxylase
Ligand
BDBM50000439
Substrate
n/a
Meas. Tech.
ChEBML_157453
IC50
149000±n/a nM
Citation
 Tucker, H; Thomas, DF Novel inhibitors of prolyl 4-hydroxylase. 2. 5-Amide substituted pyridine-2-carboxylic acids. J Med Chem 35:804-7 (1992) [PubMed]  Article 
Target
Name:
Transmembrane prolyl 4-hydroxylase
Synonyms:
Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Hypoxia-inducible factor prolyl hydroxylase 4 (HIF) | P4HTM | P4HTM_HUMAN | PH4 | Transmembrane prolyl 4-hydroxylase
Type:
Enzyme
Mol. Mass.:
56654.25
Organism:
Homo sapiens (Human)
Description:
Q9NXG6
Residue:
502
Sequence:
MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGTDSQPEWALDRAYRDARVEL
  
Inhibitor
Name:
BDBM50000439
Synonyms:
5-Butyl-pyridine-2-carboxylic acid | 5-Butyl-pyridine-2-carboxylic acid (fusaric acid) | CHEMBL24510
Type:
Small organic molecule
Emp. Form.:
C10H13NO2
Mol. Mass.:
179.2157
SMILES:
CCCCc1ccc(nc1)C(O)=O
Structure:
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