Reaction Details Report a problem with these data
Target
Nucleoside diphosphate kinase B
Ligand
BDBM50240743
Substrate
n/a
Meas. Tech.
ChEMBL_1668650 (CHEMBL4018538)
Kd
18500±n/a nM
Citation
 Wang, YQ; Huang, ZL; Chen, SB; Wang, CX; Shan, C; Yin, QK; Ou, TM; Li, D; Gu, LQ; Tan, JH; Huang, ZS Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction. J Med Chem 60:6924-6941 (2017) [PubMed]  Article 
Target
Name:
Nucleoside diphosphate kinase B
Synonyms:
2.7.13.3 | 2.7.4.6 | C-myc purine-binding transcription factor PUF | Histidine protein kinase NDKB | NDK B | NDKB_HUMAN | NDP kinase B | NM23B | NME2 | Nucleoside diphosphate kinase B | nm23-H2
Type:
PROTEIN
Mol. Mass.:
17301.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_10050
Residue:
152
Sequence:
MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE
  
Inhibitor
Name:
BDBM50240743
Synonyms:
CHEMBL4097029
Type:
Small organic molecule
Emp. Form.:
C28H33FN4O5
Mol. Mass.:
524.5838
SMILES:
COc1cc(\C=C2/CCn3c2nc2cc(NCCCN4CCOCC4)c(F)cc2c3=O)cc(OC)c1OC
Structure:
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